2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100655
    O-Desmethyl apixaban
    		99.51%
    O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
    O-Desmethyl apixaban
  • HY-133781
    cis-Clopidogrel-MP derivative
    cis-Clopidogrel-MP derivative (Clopidogrel-MP-AM) is a 3’-methoxyacetophenone derivative of Clopidogrel active metabolite. Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor.
    cis-Clopidogrel-MP derivative
  • HY-133980
    O-Demethyl Lenvatinib
    O-Demethyl Lenvatinib is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities.
    O-Demethyl Lenvatinib
  • HY-118472
    Benazeprilat
    		≥99.0%
    Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
    Benazeprilat
  • HY-100662
    Didesethyl chloroquine
    		99.91%
    Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant.
    Didesethyl chloroquine
  • HY-116831
    4′-Dihydrophaseic acid
    		98.70%
    4′-Dihydrophaseic acid is an abscisic-acid metabolite.
    4′-Dihydrophaseic acid
  • HY-137316
    Phosphoramide mustard
    Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
    Phosphoramide mustard
  • HY-W011245
    Ranitidine S-oxide
    		99.03%
    Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion.
    Ranitidine S-oxide
  • HY-12771
    O-desmethyl Mebeverine acid
    		≥99.0%
    O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    O-desmethyl Mebeverine acid
  • HY-12784
    Cycloguanil
    Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil
  • HY-133787
    Levofloxacin N-oxide
    		98.28%
    Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.
    Levofloxacin N-oxide
  • HY-100638
    RPR132595A
    RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine.
    RPR132595A
  • HY-W394903
    GS-829845
    		99.91%
    GS-829845 is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life.
    GS-829845
  • HY-118844
    Flumazenil acid
    		99.97%
    Flumazenil acid is a metabolite of Flumazenil. Flumazenil is a GABAA receptor antagonist.
    Flumazenil acid
  • HY-133794
    Dasatinib N-oxide
    		99.27%
    Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor.
    Dasatinib N-oxide
  • HY-131280
    Devaleryl Valsartan Impurity
    		99.99%
    Devaleryl Valsartan Impurity is an intermediate in the synthesis of Valsartan.
    Devaleryl Valsartan Impurity
  • HY-131579
    Deschloro Cetirizine dihydrochloride
    		99.44%
    Deschloro Cetirizine Dihydrochloride is a Cetirizine impurity. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist.
    Deschloro Cetirizine dihydrochloride
  • HY-N4173
    8-Oxoepiberberine
    		99.72%
    8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease.
    8-Oxoepiberberine
  • HY-G0014B
    Quetiapine sulfoxide hydrochloride
    Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine sulfoxide hydrochloride
  • HY-N3103
    p-Coumaric Acid Ethyl Ester
    		99.28%
    p-Coumaric Acid Ethyl Ester is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis.
    p-Coumaric Acid Ethyl Ester
Cat. No. Product Name / Synonyms Application Reactivity